Celexa® (citalopram HBr) is an orally administered discriminative serotonin reuptake inhibitor (SSRI) with a chemical arrange foreign to that of other SSRIs or of tricyclic, tetracyclic, or other ready antidepressant agents.
Celexa (citalopram hydrobromide) is to hand as tablets or as an oral solution. Celexa 10 mg tablets are skin-coated, oval tablets containing citalopram HBr in strengths equivalent to 10 mg citalopram base. Celexa 20 mg and 40 mg tablets are veil-coated, ellipsoidal , scored tablets containing citalopram HBr in strengths interchangeable to 20 mg or 40 mg citalopram base.
Citalopram HBr is a racemic bicyclic phthalane derived designated (±)-1-(3-dimethylaminopropyl)-1-(4-fluorophenyl)-1,3-dihydroisobenzofuran-5-carbonitrile, HBr with the following structural recipe, molecular method is C20H22BrFN2O and its molecular weight is 405.35. Citalopram HBr occurs as a penalize, so amoxil hoary to off-white powder. Citalopram HBr is sparingly soluble in bedew dilute and soluble in ethanol.
The tablets also confine the following placid ingredients: copolyvidone, corn starch, crosscarmellose sodium, glycerin, lactose monohydrate, magnesium stearate, hypromellose, microcrystalline cellulose, polyethylene glycol, and titanium dioxide. Iron oxides are second-hand as coloring agents in the beige (10 mg) and pink (20 mg) tablets. Celexa oral working contains citalopram HBr equivalent to 2 mg/mL citalopram ignoble. It also contains the following unmoving ingredients: sorbitol, purified damp, propylene glycol, methylparaben, usual peppermint flavor, and propylparaben.
The antidepressant action of Celexa in hospitalized depressed patients has not been adequately studied. The efficacy of Celexa in maintaining an antidepressant response for up to 24 weeks following 6 to 8 weeks of acute doctoring was demonstrated in two placebo-controlled trials (imagine CLINICAL PHARMACOLOGY).
Celexa (citalopram HBr) is indicated because of the treatment of sadness. The efficacy of Celexa in the remedy of recess was established in 4-6 week, controlled trials of outpatients whose diagnosis corresponded most closely to the DSM-III and DSM-III-R listing of major depressive bedlam (sort out CLINICAL PHARMACOLOGY). A bigger depressive adventure (DSM-IV) implies a prominent and relatively persistent (more every day championing at least 2 weeks) depressed or dysphoric inclination that usually interferes with always functioning, and includes at least five of the following nine symptoms: depressed eager, sacrifice of engross in regular activities, important metamorphosis in burden and/or keenness, insomnia or hypersomnia, psychomotor agitation or retardation, increased drain, feelings of contriteness or worthlessness, slowed thinking or impaired concentration, a suicide attack or suicidal ideation.
Nevertheless, the physician who elects to use Celexa throughout extended periods should periodically re-rate the fancy-relating to help of the medication fit the unitary valetudinarian . DOSAGE AND ADMINISTRATION Initial Treatment Celexa (citalopram HBr) should be administered at an original amount of 20 mg once common, generally with an advance to a dose of 40 mg/day. Dose increases should for the most part chance in increments of 20 mg at intervals of no less than united week.
Celexa should be toughened with in patients with Spartan renal impairment. Treatment of Pregnant Women During the Third Trimester Neonates exposed to Celexa and other SSRIs or SNRIs, late in the third trimester, father developed complications requiring prolonged hospitalization, respiratory assistance, and tube feeding (inquire about bid adieu PRECAUTIONS). When treating pregnant women with Celexa during the third trimester, the physician should carefully cogitate on the implicit risks and benefits of doctoring. The physician may consider tapering Celexa in the third trimester.
Although in the cards patients may call for a dose of 60 mg/day, the only study fitting to measure comeback seeing that effectiveness did not picket an profit for the 60 mg/light of day quantity over the 40 mg/light of day administer; doses above 40 mg are as a result not ordinarily recommended. Celexa should be administered once constantly, in the morning or evening, with or without viands. Special Populations 20 mg/age is the recommended administer championing most old-age pensioners patients and patients with hepatic harm, with titration to 40 mg/heyday only in behalf of nonresponding patients. No dosage regulation is necessary over the extent of patients with emollient or reduce renal imperfection.
Celexa (citalopram hydrobromide) is to hand as tablets or as an oral solution. Celexa 10 mg tablets are skin-coated, oval tablets containing citalopram HBr in strengths equivalent to 10 mg citalopram base. Celexa 20 mg and 40 mg tablets are veil-coated, ellipsoidal , scored tablets containing citalopram HBr in strengths interchangeable to 20 mg or 40 mg citalopram base.
Citalopram HBr is a racemic bicyclic phthalane derived designated (±)-1-(3-dimethylaminopropyl)-1-(4-fluorophenyl)-1,3-dihydroisobenzofuran-5-carbonitrile, HBr with the following structural recipe, molecular method is C20H22BrFN2O and its molecular weight is 405.35. Citalopram HBr occurs as a penalize, so amoxil hoary to off-white powder. Citalopram HBr is sparingly soluble in bedew dilute and soluble in ethanol.
The tablets also confine the following placid ingredients: copolyvidone, corn starch, crosscarmellose sodium, glycerin, lactose monohydrate, magnesium stearate, hypromellose, microcrystalline cellulose, polyethylene glycol, and titanium dioxide. Iron oxides are second-hand as coloring agents in the beige (10 mg) and pink (20 mg) tablets. Celexa oral working contains citalopram HBr equivalent to 2 mg/mL citalopram ignoble. It also contains the following unmoving ingredients: sorbitol, purified damp, propylene glycol, methylparaben, usual peppermint flavor, and propylparaben.
The antidepressant action of Celexa in hospitalized depressed patients has not been adequately studied. The efficacy of Celexa in maintaining an antidepressant response for up to 24 weeks following 6 to 8 weeks of acute doctoring was demonstrated in two placebo-controlled trials (imagine CLINICAL PHARMACOLOGY).
Celexa (citalopram HBr) is indicated because of the treatment of sadness. The efficacy of Celexa in the remedy of recess was established in 4-6 week, controlled trials of outpatients whose diagnosis corresponded most closely to the DSM-III and DSM-III-R listing of major depressive bedlam (sort out CLINICAL PHARMACOLOGY). A bigger depressive adventure (DSM-IV) implies a prominent and relatively persistent (more every day championing at least 2 weeks) depressed or dysphoric inclination that usually interferes with always functioning, and includes at least five of the following nine symptoms: depressed eager, sacrifice of engross in regular activities, important metamorphosis in burden and/or keenness, insomnia or hypersomnia, psychomotor agitation or retardation, increased drain, feelings of contriteness or worthlessness, slowed thinking or impaired concentration, a suicide attack or suicidal ideation.
Nevertheless, the physician who elects to use Celexa throughout extended periods should periodically re-rate the fancy-relating to help of the medication fit the unitary valetudinarian . DOSAGE AND ADMINISTRATION Initial Treatment Celexa (citalopram HBr) should be administered at an original amount of 20 mg once common, generally with an advance to a dose of 40 mg/day. Dose increases should for the most part chance in increments of 20 mg at intervals of no less than united week.
Celexa should be toughened with in patients with Spartan renal impairment. Treatment of Pregnant Women During the Third Trimester Neonates exposed to Celexa and other SSRIs or SNRIs, late in the third trimester, father developed complications requiring prolonged hospitalization, respiratory assistance, and tube feeding (inquire about bid adieu PRECAUTIONS). When treating pregnant women with Celexa during the third trimester, the physician should carefully cogitate on the implicit risks and benefits of doctoring. The physician may consider tapering Celexa in the third trimester.
Although in the cards patients may call for a dose of 60 mg/day, the only study fitting to measure comeback seeing that effectiveness did not picket an profit for the 60 mg/light of day quantity over the 40 mg/light of day administer; doses above 40 mg are as a result not ordinarily recommended. Celexa should be administered once constantly, in the morning or evening, with or without viands. Special Populations 20 mg/age is the recommended administer championing most old-age pensioners patients and patients with hepatic harm, with titration to 40 mg/heyday only in behalf of nonresponding patients. No dosage regulation is necessary over the extent of patients with emollient or reduce renal imperfection.
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