Venlafaksin does not influence on farmakokinetiku lithium.At simultaneous application with imipraminom farmakokinetika venlafaksina and ODV does not change.At joint application with galoperidolom the effect of the last from the increase of level preparation increases in blood.At simultaneous application with diazepamom of farmakokinetika preparations and their basic metabolitov does not change substantially. Also it is not discovered influence on the psikhomotornye and psikhometricheskie effects of diazepama.
At simultaneous application with klozapinom there can be an increase of his level in plasma of blood and development of effects of sides (for example epileptic attacks).At simultaneous application with risperidonom (in spite of multiplying AUC risperidona) farmakokinetika of sum of active components (risperidona and his active metabolita) did not change substantially.Strengthens influence of alcohol on psikhomotornye reactions. On a background adopting venlafaksina it is necessary to observe the special carefulness at electro-convulsive therapy, as experience of application of venlafaksina is absent in these terms. Atlanta zyprexa lawyers Medicinal preparations, metaboliziruemye izofermentami of tsitokhroma of P 450: the enzyme of CYP2D6 of the system of tsitokhroma of P 450 will transform venlafaksin in active metabolit — ODV. Unlike many other antidepressants, the dose of venlafaksina can be not reduced at simultaneous introduction with preparations, repressing activity of CYP2D6, or setting patients with the genetically conditioned decline of activity of CYP2D6, as a total concentration of velafaksina and ODV.
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