Method of application and dose: Inward, during a meal. The recommended initial day's dose makes 75 mgs in 2 receptions (for 37,5 mgs).
If, in opinion of doctor, more high dose (at the heavy depressed disorder or other states, requiring stationary treatment) is needed, it is possible at once to appoint 150 mgs in 2 receptions (for 75 mgs 2 times per a day). After it day's dose can be multiplied on 75 mgs each 2–3 days to achieving the desired therapeutic effect. Maximal day's dose is 375 mgs. After achieving a necessary therapeutic effect day's dose can be gradually reduced to the minimum effective level.Supporting therapy and prophylaxis of relapses: supporting treatment can proceed 6 mes and more. Minimum effective doses, used at treatment of the depressed episode, are appointed.Kidney insufficiency: at easy kidney insufficiency (SKF are more than 30 ml/mines) of correction of the mode of dosage not required;
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