Lexapro and pregnancy

The basic way of destroying of lexapro and pregnancy is included by metabolism with participation CYP2D6 and CYP3A4, it is therefore necessary to observe a carefulness at setting of venlafaksina with LS, oppressive both these the enzyme. Such medicinal co-operations are not yet explored.Venlafaksin — relatively weak ingibitor of CYP1D6 and does not repress activity of izofermentov of CYP1A2, CYP2C9 and CYP3A4, therefore it is not necessary to expect his co-operating with other preparations, these enzymes participate in metabolism of which.Tsimetidin represses metabolism of the "first passing" of venlafaksina and does not influence on farmakokinetiku ODV. At most patients the insignificant increase of general pharmacological activity of venlafaksina and ODV is expected only (it is more expressed for elderly patients and at violation of function of liver).

Clinically with antihypertense (including beta-blokatorami, ingibitorami of APF and diuretikami) and противодиабетическими preparations not found out the meaningful co-operating.Binding to the squirrel of plasma of blood makes for venlafaksina — 27%, for ODV — 30%. Therefore preparation does not influence on the concentration of LS, possessing the high degree of binding to the squirrel, in plasma of blood.
At a simultaneous reception the antikoagulyantnyy effect of the last can increase with varfarinom.At a simultaneous reception farmakokinetika indinavira (with a 28%-ным diminishing of AUC and 36% diminishing of Cmax) changes with indinavirom, and farmakokinetika venlafaksina and ODV does not change. The clinical value of this effect is unknown.